What Are The Symptoms Of Pyroluria & Is There A Pyrrole Disorder Treatment Plan?
You may have heard the term Pyrrole, Pyrroluria, Pyrrole Disorder, Kryptopyrole, or even Mauve Factor: they are all referring to a condition that results in an overproduction of pyrroles or hydroxyhaemopyrrolin-2-one (HPL). But what is Pyroluria or Pyrrole Disorder? What are the symptoms and how can it be treated? In this blog post we aim to highlight some of the most common symptoms that people experience, how to establish whether Pyroluria is the issue and how we develop a pyrrole disorder treatment plan to support patients with elevated levels of HPL.
What Is Pyrrole Disorder?
Pyrrole Disorder is an abnormality in biochemistry resulting in the overproduction of a haemoglobin metabolite known as hydroxyhemopyrrolin-2-one (HPL) – or simply “urinary pyrrole”. This HPL molecule, is a by-product of red blood cell production which is excreted from the body via the kidney and into urine. The HPL molecule has a strong affinity for B6 and zinc which it binds to – stripping our reserves then forcing their excretion.
Can the stripping of B6 and Zinc really be such a big deal? YES it can: B6 and zinc are critical for many of our bodies major processes such as digestion, immune function, and they are the raw materials needed to make the neurotransmitters that make us feel happy and calm: GABBA & Serotonin. They are also crucial in balancing our hormones: ensuring we don’t have breast tenderness, heavy periods.
Understanding that the disorder is an increase in the excretion primarily of zinc and B6, the signs and symptoms of pyrrole disorder closely follow that of a B6 and zinc deficiency Pyroluria affects up to 10% of the population, and the incidence can increase to 18-35% in people with psychological disturbances, learning or behavioural problems. Think you may have pyroluria? Do you tick yes to experiencing any of the below?
Common Pyrrole Disorder Symptoms
- Mood and behavioural symptoms (e.g. anxiety and stress intolerance, depression, inner tension, social withdrawal, explosive temper and mood swings)
- Abdominal pain and/or morning nausea
- Impotence in males
- Acne
- Irregular periods and/or delayed puberty
- Allergies and intolerances
- Sensitivity to light, sound and odour
- Migraines
- Attention deficiency/hyperactivity
- Irritable Bowel Syndrome
- Poor dream recall
- Stretch marks in the skin and/or white spots on fingernails
What Makes Pyrrole Disorder Worse?
Pyrrole disorder is exacerbated by stress and traumatic events. From starting school, a new job, the onset of menopause, or periods, a marriage breakdown, redundancy, new carer anything that an individual finds significantly stressful can exacerbate symptoms (when we can least afford it too!).
Food intolerances and impaired methylation are often seen with pyrrole disorder and can magnify its effect.
Zinc and copper ratios sit on opposite ends of a seesaw therefore avoiding high copper foods, copper bracelets and copper water pipes is crucial in these patients as it further exacerbates a zinc deficiency.
Is Pyrrole Disorder Genetic?
Pyroluria is genetic: a child of a parent with Pyrrole disorder has a 50% chance of it being passed onto them, if both parents are pyrrole positive there is a 75% chance of offspring inheriting the disorder; which is why I often suggest to families if one family member is effected its worth investigating the rest of family.
How Do I Know If I Have Pyroluria?
A pyrrole test is a very sensitive urine test that simply tests for the concentration of HPL in the urine. Samples containing levels of urinary HPL of 0 – 10 μg/dL are considered normal or negative, samples of 10 – 20 μg/dL are considered borderline, and samples above 20 μg/dL are considered elevated. We choose to use a laboratory that specialises only in pyrrole testing, because it is such a sensitive test. Pyrroles are extremely sensitive to light and heat and so a urine sample must be collected in an environment with the least exposure to light as possible, in a container with a preserving agent, wrapped in alfoil upon sample collection, snap frozen and then sent to the testing laboratory on dry ice. If this procedure is not followed correctly then false negatives or low HPL readings are possible. Your practitioner will guide you through the collection instructions. Pyrrole testing costs between $75-$135.
Is There An Effective Pyrrole Disorder Treatment Plan?
A Pyrrole disorder treatment plan is often more complex than supplementing with vitamin B6 and zinc. There is not a ‘one-approach-fits-all’ patients solution. We determine the most appropriate nutrients at the right levels for you. Pyrroles are highly oxidative so your treatment will often involve some antioxidant nutrients to combat that component of the disorder.
Nutrients include: Vitamin B6, pyridoxine-5-phosphate (the active form of Vitamin B6) zinc and magnesium. Other supportive nutrients may include: Vitamin C, Vitamin E, and evening primrose oil, Vitamin D, B12, Vitamin A and Biotin and manganese.
In some cases, we may suggest we compound your nutrients specifically for you to achieve optimal dosing. This is assessed on a case by case basis. We also have the ability to dose some nutrients via creams for young children or those who battle taking tablets.
While nutrient supplementation is one form of treatment for pyroluria there are also a whole lot of other factors that will impact a treatment plan. HPL may be a stress-induced factor. It has been proposed that emotional and physical stress increases HPL excretion very quickly. It is also believed that stress and high HPL may affect the production of heme, the iron carrier in red blood cells. This has a detrimental effect on energy production and increases oxidative damage to the cells, as the body is unable to produce enough antioxidants and other important detoxification factors. Research also suggests dysbiosis and intestinal permeability can lead to higher circulating levels of HPL (and zinc is important for the maintenance of intestinal integrity). Therefore improving intestinal integrity and addressing dysbiosis may be an important step in reducing urinary HPL.
Genetics is another factor for us to take into consideration. Poor vitamin B6 and zinc status will negatively impact healthy methylation processes, which is confounded by the presence of SNPs on genes encoding for enzymes involved in methylation. We do not have one treatment plan that fits all. Your practitioner is here to look at the big picture, we will consider each of the above in conjunction with a full health assessment to get you onto an individualised pyrrole disorder treatment plan specific for you!
How Long Before Pyrrole Disorder Symptoms Subside?
Your level of deficiency will dictate how long it takes to feel the better. Those with mild or moderate symptoms of Pyrrole Disorder may see a dramatic response very quickly in as little as a week to four weeks. Those with more severe symptoms usually require one to three months before some improvement is seen, and then gradually greater improvement over 3-12 months. The team at Perpetual Wellbeing can help you. Book an appointment today with one of our expert practitioners.
FAQs About Pyroluria and Pyrrole Disorder
Pyrrole disorder, also known as pyroluria, is a biochemical imbalance associated with elevated levels of hydroxyhaemopyrrolin-2-one, or HPL, in the urine. HPL can bind to nutrients such as vitamin B6 and zinc, which may contribute to symptoms linked with low levels of these important nutrients.
Common symptoms associated with pyroluria may include anxiety, mood swings, stress intolerance, poor dream recall, sensitivity to light or sound, digestive discomfort, acne, irregular periods, allergies, migraines, fatigue, poor concentration, white spots on the nails and stretch marks on the skin. Symptoms vary from person to person.
Stress is one of the most common triggers for worsening pyrrole disorder symptoms. Major life changes, trauma, illness, hormonal shifts, food intolerances, poor gut health and impaired methylation may also contribute. Because zinc and copper need to stay in balance, high copper exposure may also worsen symptoms in some people.
Pyroluria is commonly assessed through a specialised urine test that measures HPL levels. Because pyrroles are sensitive to heat and light, the sample needs to be collected and transported carefully to reduce the risk of inaccurate results. Your practitioner will provide clear instructions if testing is recommended.
Yes. A pyrrole disorder treatment plan usually focuses on restoring nutrient balance, reducing oxidative stress and addressing contributing factors such as stress, gut health, food intolerances or methylation issues. Treatment often includes specific forms of vitamin B6, zinc and other supportive nutrients, but the right approach depends on your individual results and symptoms.
It is not recommended to self-prescribe high doses of zinc or vitamin B6 without guidance. The right form, dose and combination of nutrients can vary, and excessive supplementation may create new imbalances. Working with an experienced practitioner helps ensure your treatment plan is safe, targeted and monitored properly.
Some people notice improvements within days or weeks, while others need longer-term support. Treatment is often recommended for at least 12 weeks to allow nutrient levels and symptoms to stabilise. Progress can vary depending on stress levels, deficiency severity, gut health and how long symptoms have been present.
Yes, pyroluria may affect mood and stress tolerance because zinc and vitamin B6 are involved in neurotransmitter production, including serotonin, dopamine and GABA. Low levels of these nutrients may contribute to anxiety, inner tension, emotional sensitivity, mood swings or difficulty coping with stress.
Gut health may play a role in pyrrole disorder for some people. Dysbiosis, inflammation and increased intestinal permeability may contribute to higher HPL levels or worsen symptoms. This is why a treatment plan may include support for digestion, gut integrity and food intolerances alongside nutrient therapy.
It may be worth seeking support if you experience ongoing anxiety, stress intolerance, mood swings, poor dream recall, digestive symptoms, fatigue, hormonal issues or sensitivity to light, sound or smells. A practitioner can assess whether pyroluria may be contributing to your symptoms and recommend appropriate testing and treatment.
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