Genetic Methylation Test

We offer a comprehensive genetic methylation profile test and methylation nutrient testing that provides detailed insights into your genetic markers and how well your methylation pathways are functioning.

What Is A Gene Methylation Test?

A genetic methylation test can provide meaningful insights into your biochemical and genetic predispositions, particularly around gene regulation, detoxification, and cardiovascular and mental health.

We have methylation genetic testing available for assessing ones genetic variations such as:

  • MTHFR 677
  • MTHFR 1298
  • MTR
  • MTRR
  • COMT

For more information about the testing we have available to assess genetics, please refer to our myDNA Health and Methylation Genetic panel.

How Much Does A Genetic Methylation Test Cost?

The below offer applies only to the myDNA Comprehensive Health and Methylation Genetic Panel, and available only in Australia:

  1. Purchase the myDNA Comprehensive Health and Methylation Genetic Panel for $360, and get the report and interpretation guide emailed to you. Please contact us for details on how to purchase this kit.
  2. Get one of our practitioners to request it for you during an initial consultation for $285. (Initial consultation fees apply). Book your initial consultation here.
  3. It is highly recommended to book in for a results interpretation appointment, for the practitioner to personalise recommendations and further relevant nutrient testing if deemed clinically relevant. (Only for patients that have already attended an initial consultation at our clinic)

What Is The Link Between Genetics & Methylation?

The Methylation test panel is an innovative testing solution that looks at whether your methylation cycle is working effectively.

What Is Methylation?

Methylation is a chemical process that happens billions of times per second in every cell of the body. Methylation is a process where certain nutrients called ‘methyl donors’ are added to specific elements of DNA, our gene markers and proteins that keep them physiologically active. Methyl groups are transferred and donated between many different molecules which change their structure and function. Methyl groups act like billions of switches which turn genes on or off, help regulate mood, detoxify hormones, produce energy, and promote healthy aging.

Vitamins, minerals, and amino acids from the diet are needed to keep this process running smoothly. There are also genetic factors and oxidative stressors which can affect how well this pathway works.

Methylation is a major pathway to focus on in understanding autoimmune and neurological diseases such as multiple sclerosis, seizure disorders, dementia, chronic fatigue syndrome, lupus, depression, anxiety and autism spectrum disorders. Methylation is responsible for making, maintaining and repairing DNA.

The methylation cycle is a biochemical pathway that manages or contributes to a wide range of biochemical functions: detoxification, supporting DNA (turning genes on and off), producing energy, reducing inflammation, synthesising neurotransmitters, homocysteine metabolism, protein methylation, phase 2 liver detoxification and supporting immune function.  Inadequate methylation capacity can lead to birth defects, depression, cognitive decline, and cancer.  Impaired methylation has even been associated with autism.  Support of methylation markers has been associated with rapid return of speech, improvement of behaviour in ADD and ADHD spectrums.

genetic methylation test offered by perpetual wellbeing

Methylation Nutrient Testing

We also have testing available to assess the level of nutrients and markers involved in the methylation cycle, such as:

  • 5-methyl tetrahydrofolate (5MTHF)
  • Folinic acid
  • S-Adenosyl Homocysteine (SAH)
  • S-Adenosyl Methionine (SAMe)
  • SAMe:SAH ratio
  • Tetrahydrofolate (THF)
  • Active Vitamin B12
  • Homocysteine
  • Serum Folate

Make an appointment with one of our Clinical Nutritionists or Naturopaths to be tested for markers involved in Methylation.

An appointment is needed first, prior to us requesting the Methylation nutrient panel. The cost of this panel ranges from $29.70 for a single marker to $497 for the full panel.

What are the common symptoms and conditions associated with MTHFR polymorphisms?

  • Alcohol withdrawal seizure
  • Hypertension
  • Autism
  • Increased breast cancer risk (women >55 years)
  • Cardiovascular disease: thromboembolism, therosclerosis, and myocardial infarction
  • Neural tube and other birth defects
  • Colorectal neoplasias
  • Peripheral neuropathy
  • Dementia and memory loss
  • Reduced lean body mass and increased body fat
  • Depression and irritability
  • Schizophrenia
  • Elevated homocysteine
  • Stroke

Genetic Methylation Test Price

Book an online consultation or a face to face appointment at our Brisbane or Graceville clinics with one of our naturopaths and let us help you understand if methyl folate deficiency is an underlying cause of your health issues.

test pricing guide is available here.

FAQs About Genetic Methylation Testing

A genetic methylation test examines chemical modifications on your DNA, known as methylation, that influence how genes are switched on or off without changing the underlying genetic code. These epigenetic changes play a key role in essential functions like detoxification, hormone balance, nutrient absorption, DNA repair and immune response.

Yes. Genetic methylation testing is available across Australia, offered both via clinics and through at-home kits depending on the provider. It is recommended that you have a health practitioner interpret the results for you.

Methylation testing can provide meaningful insights into your biochemical and genetic predispositions, particularly around gene regulation, detoxification and cardiovascular and mental health. While the science is still evolving and not every detected variation has a direct therapeutic path, these tests are a valuable tool to help inform personalised wellness strategies.

The process is typically straightforward:

  1. Choose a test, either online or through a clinic

  2. Provide a sample, commonly saliva, blood or a cheek swab

  3. Send it to the lab, which may be an accredited facility

  4. Receive a report detailing your methylation pattern, often supported by tailored recommendations for nutrition, supplements or lifestyle changes

At Perpetual Wellbeing we recommend coming into the clinic to get your test results interpreted and explained.

They can be, especially for individuals seeking insight into underlying metabolic or biochemical issues such as fatigue, mood fluctuations, hormone imbalances or poor detox capacity. These tests can help guide personalised interventions and preventative health measures. However, interpreting the results with the help of a qualified practitioner ensures they are genuinely useful.


What We Can Help With

The team at Perpetual Wellbeing support the health and wellbeing of the whole family. We promote a more scientifically-based approach to natural healthcare, to help detect the root cause of health issues and treat patients for long-term good health.

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Kenmore Clinic

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